Leveraging our clinically-validated masking technology and capabilities to advance a pipeline of differentiated masked I-O therapies for validated targets

Our tumor-selective I-O therapies are designed to unlock the potential for durable efficacy by focusing anti-tumor activity within the tumor microenvironment without severe side effects associated with systemically active I-O agents.

NSCLC and other solid tumors

XTX501

Bispecific PD-1 / masked IL-2

Prostate

PSMA+STEAP1

Multi-specific, masked T cell engager with co-stimulation (SEECR)

Gastric, pancreatic, esophageal, lung

CLDN18.2

Masked T cell engager

Advanced solid tumors

Efarindodekin alfa

Masked IL-12