12/12/2023
XTX101 Publication in Journal for ImmunoTherapy of Cancer
XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer

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12/07/2023
XTX101 Poster Presentation at the 2023 European Society for Medical Oncology (ESMO) Immuno-Oncology Congress
Phase 1/2 Study of XTX101, a masked, tumor-activated Fc-enhanced anti-CTLA-4, in patients with advanced solid tumors

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11/30/2023
XTX301 Publication in Molecular Cancer Therapeutics
XTX301, a tumor-activated Interleukin-12 has the potential to widen the therapeutic index of IL-12 treatment for solid tumors as evidenced by pre-clinical studies

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11/04/2023
XTX301 Poster Presentation at the 2023 Society for Immunotherapy of Cancer’s (SITC) 38th Annual Meeting
XTX301, a tumor-activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models

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11/03/2023
XTX202 Poster Presentation at the 2023 Society for Immunotherapy of Cancer’s (SITC) 38th Annual Meeting
XTX202-01, Phase 1/2 first-in-human study of XTX202, a masked, tumor-activated IL-2βγ, in patients with advanced solid tumors

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06/30/2023
XTX301 Poster Presentation at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting
A first-in-human study of XTX301, a masked, tumor-activated interleukin-12 (IL-12) in patients with advanced solid tumors

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04/16/2023
XTX301 Poster Presentation at the American Association for Cancer Research (AACR) 2023 Annual Meeting
A half-life extended, tumor-activated IL-12 increased the infiltration of effector immune cells into the tumor microenvironment and demonstrated anti-tumor activity in syngeneic mouse models

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04/16/2023
PD1/IL-2 Multifunctional Poster Presentation at the American Association for Cancer Research (AACR) 2023 Annual Meeting
Tumor-activated PD1-directed IL-2 increased antigen specific T cells in tumors and demonstrated anti-tumor activity in mice

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11/10/2022
XTX202 Poster Presentation at the 2022 Society for Immunotherapy of Cancer’s (SITC) 37th Annual Meeting
XTX202, a tumor-selective protein-engineered IL-2, exhibited enhanced anti-tumor activity in combination with checkpoint inhibition in mice

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06/05/2022
XTX202 Poster Presentation at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting
A First-in-Human, Multicenter, Phase 1/2, Open-Label Study of XTX202, a Tumor-Selective Interleukin-2 (IL-2), in Patients with Advanced Solid Tumors

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05/10/2022
XTX301 Poster Presentation at the New York Academy of Sciences’ Frontiers in Cancer Immunotherapy 2022 Conference
A half-life extended, tumor selective IL-12 activated tumor infiltrating immune cells and demonstrated anti-tumor activity in the MC38 syngeneic mouse model

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11/12/2021
XTX301 Poster Presentation at the Society for Immunotherapy in Cancer’s 36th Annual Meeting (SITC)
XTX301, A Protein-engineered IL-12, Exhibits Tumor-selective Activity In Mice Without Peripheral Toxicities And Is Well Tolerated In Non-Human Primates

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11/12/2021
XTX101 (CTLA-4) Poster Presentation at the Society for Immunotherapy in Cancer’s 36th Annual Meeting (SITC)
A First-in-Human, Multicenter, Phase 1/2, Open-Label Study of XTX101 in Patients with Advanced Solid Tumors

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10/17/2021
Poster Presentation at the 9th Annual Meeting of the International Cytokine and Interferon Society (ICIS)
Engineering Geographically Precise Activation of Cytokines To Achieve Improved Therapeutic Benefit in Oncology and Beyond

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09/22/2021
Presentation at the Next-Gen Cytokine Therapeutics Summit
Tumor selective cytokines for cancer therapy

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06/08/2021
XTX202 (IL-2) Poster Presentation at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting
XTX202, a protein-engineered IL-2, exhibits tumor-selective activity in mice without peripheral toxicities in non-human primates

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05/12/2021
XTX101 (CTLA-4) Poster Presentation at The New York Academy of Sciences’ Frontiers in Cancer Immunotherapy 2021 Virtual Symposium
Tumor-Activated Anti-CTLA-4 Monoclonal Antibody, XTX101, Demonstrates Monotherapy and Anti-PD-1 Combination Benefit in Preclinical Models

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11/13/2020
XTX101 (CTLA-4) Poster Presentation at 35th Annual Meeting of The Society for Immunotherapy of Cancer
Tumor-activated Fc-engineered Anti-CTLA-4 Monoclonal Antibody, XTX101, Demonstrates Tumor-selective PD and Efficacy in Preclinical Models

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11/12/2020
XTX201 (IL-2) Poster Presentation at 35th Annual Meeting of The Society for Immunotherapy of Cancer
XTX201, a protein-engineered IL-2, exhibits tumor-selective activity in mice without peripheral toxicities in non-human primates

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